Nanosphere to Report 3rd Quarter Results & Hold Investor Conference Call on Thursday, December 13, 2007

NORTHBROOK, IL, December 6,  2007—Nanosphere, Inc., (NASDAQ: NSPH), which develops, manufactures and markets advanced molecular diagnostics systems, will announce its results for the third quarter of 2007 prior to the market opening on Thursday, December 13, 2007. The company will also hold a live conference call and webcast for investors that morning at 10:30 A.M., Eastern Standard Time.

The teleconference can be accessed by dialing 866-510-0705 (U.S./Canada) or 617-597-5363 (international), participant code 98769147. The call will also be broadcast live over the Internet and can be accessed by interested parties at the Investor Relations tab on the Nanosphere website: www.nanosphere.us. For interested individuals unable to join the call or webcast, a replay will be available through Thursday, December 27, 2007, by dialing 888-286-8010 or for international calls 617-801-6888, pass code 89061695, or on the company’s website.

About Nanosphere, Inc.
Nanosphere develops, manufactures and markets an advanced molecular diagnostics platform, the Verigene® System for direct genomic and ultra-sensitive protein detection. This easy-to-use and cost-effective platform enables simple, low-cost and highly sensitive genomic and protein testing on a single platform. Nanosphere is based in Northbrook, IL. Additional information is available at www.nanosphere.us.